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Migraine Defense

Migraine Defense

$65.00
$70.00 $65.00
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30-day supply. Delivered to your door automatically each month.

Formulated For Lasting Relief

We know how debilitating it can be to live with migraine. That's why we've developed a scientifically backed formula to help you take your life back. Our unique physician developed blend targets the key nutrient deficiencies that have been linked to migraine, to reduce the frequency, severity, and duration of attacks using only the highest quality ingredients that have been rigorously tested for safety and efficacy.

What's Inside

Magnesium Glycinate

Magnesium is often heralded as a keystone migraine defense supplement—it's also one of the most confusing. It comes in many forms, and what you grab from your pharmacy or big box retailer is often something like Magnesium Oxide or Magnesium Citrate—cheaper, less bioavailable forms, which means your body absorbs less of the intended nutrient and more ends up leaving your body in a hurry (in other words, they are great laxatives).

One of the most bioavailable forms of magnesium, glycinate is gentle on the stomach and highly effective for supporting healthy nerve function. Studies have shown that taking the right form of magnesium can help reduce the number of migraine days you experience by more than 40%. Unlike other forms of magnesium, glycinate works on your migraine—not your, um, bowels.

Coenzyme Q10

Coenzyme Q10 (otherwise known as CoQ10) is an antioxidant that supports cellular energy production, and multiple studies have shown that CoQ10 supplementation alone can significantly reduce the frequency of migraine attacks. One meta-analysis found that CoQ10 could reduce the number of migraine days by as much as 30%.

Curcumin + Piperine

Curcumin is known for its anti-inflammatory properties, and helps combat the inflammation that can trigger migraines. When combined with piperine—which is found in black pepper extract, absorption is enhanced and curcumin becomes even more effective.

Here's where things get interesting: studies have also shown a significant synergistic effect of curcumin and CoQ10 on clinical features of migraine—very good news if you take Migraine Defense, (and very bad news if you're a migraine).

Alpha Lipoic Acid

This powerful antioxidant helps reduce oxidative stress, which is linked to migraine development and essential for preventing attacks​. Studies suggest that alpha lipoic acid may help reduce both the frequency and intensity of migraines by supporting mitochondrial function.

Directions: Take one pack every morning with food and a full glass of water. Consistency is key—our formula is designed to work best when taken daily.

Looking For Something Custom?

Every migraine journey is unique—so sometimes one size doesn't fit all.

Whether you're looking to add extra support for your specific triggers or remove ingredients that don't work for your body, we're here to help you create a formula that fits your needs.

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Inspired by migraine

Made For Migraine

Not all supplement brands are created equal. Cheaper magnesium forms like magnesium oxide and citrate? More likely to upset your stomach than help with migraine.

Migraine Defense delivers more by combining the right ingredients, together for maximum effectiveness. Research shows that key components in Migraine Defense create a powerful synergistic effect—becoming more effective than when taken individually.

Safety & Quality

Rigorously Tested For Peace Of Mind

Every ingredient of our supplements is tested by independent, third-party laboratories to ensure adherence to Good Manufacturing Practices (GMP) and FDA guidelines. This extra step ensures that we meet strict purity, potency, and safety standards that aren’t always guaranteed with brands that exclusively test in-house.

By relying on unbiased testing to ensure they are free from contaminants – like heavy metals, pesticides, and harmful microbes – you can feel confident that what’s in your capsule matches what’s on the label.

Convenient and sustainable

Eco-Friendly And Convenient Packaging

We’ve designed our packaging to not only deliver powerful migraine prevention but also reduce environmental impact. Each monthlong supply comes in a recyclable cardboard cartridge that uses 80% less plastic than traditional supplement bottles.

Inside, you'll find 30 individual, easy-to-use daily packs. Simply grab a pack in the morning and take it with food and water for a convenient, sustainable way to support your migraine prevention routine.

Recommended By Doctors

"I highly recommend Mindset Migraine Defense as an effective and reliable solution for migraine care.

Mindset's formula provides comprehensive relief, with ingredients chosen for their bioavailability, clinical support, and cost-effectiveness -- in my experience, it has significantly reduced or eliminated migraine attacks in both chronic and episodic cases."

-- Dr. Gretchen Sibley, DO
Board Certified in Neuromusculoskeletal / Osteopathic Manual Medicine

Trusted By Migraine Sufferers

  • 70% attack reduction

    I bought Mindset for my husband, who was suffering from multiple bad headaches every week...he started taking Mindset at my recommendation (even though he was convinced it wouldn’t work) and he saw results in just a few weeks. Since he started Mindset, his headaches have become about 70% less frequent and the ones he does are less debilitating.

    -Courtney B

  • Noticeable improvement

    My entire routine has changed since I started taking Mindset. My migraine attacks have reduced from every other week to once a quarter at most. I love how easy it is to grab my supplements with this approach.

    -Liz K

  • Game changer

    I had tried different supplements before, but I decided to give Mindset a try based on the better ingredient profile. The results have been life-changing -- I just went a whole year without an attack. I’m so grateful to have something that finally works!

    -John C
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See How We Stack Up

Mindset Other Supplements
Bioavailable ingredients ✓ ✗
Dosage amounts meant for migraine ✓ ✗
Customizable formula plans ✓ ✗
Blended in the USA ✓ ✓
Individually dosed packets ✓ ✗
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Frequently Asked Questions

How long does shipping take?

Orders are typically processed and shipped within three business days.

Can Mindset be taken with prescription migraine medications?

Many of our customers use Mindset to significiantly reduce the frequency of their migraines, while keeping prescription medications like triptans on hand to treat occasional breakthrough attacks. Our ingredients have been shown in studies to help reduce attack frequency, and may also help lessen the intensity and duration of attacks.

Why is it important to take with food and a full glass of water?

When food hits your stomach, it triggers your body to release digestive acids -- which help start to break down and ingest the nutrients. It also helps slow down digestion, and minimizes contact with the stomach lining -- all of which help optimize absorption, minimize digestive issues, and enhance overall effectiveness.

Staying hydrated is also key since dehydration is a known migraine trigger for up to 50% of migraineurs. Many of our customers report that simply starting the day off consistently with a full 8oz glass of water and a light bite along with their migraine pack made a significant difference in their quality of life.

Are Mindset formulas meant to be taken long-term?

The ingredients in our formulas are all Generally Recognized As Safe (GRAS), making them suitable for long-term use. They’re designed to be taken daily, allowing the nutrients to build up in your system over time. As always, we recommend consulting with a healthcare provider before starting any new supplement, especially if you're taking medications or managing other health conditions.

How long before I should expect to see results?

Results vary, but many people start noticing improvements within a few weeks. However, it can take up to 90 days to see the full benefits, as the nutrients build up in your system over time.

What makes Mindset different from other migraine supplements? 

Mindset combines clinically researched ingredients in optimal forms and dosages, ensuring they work together for maximum effectiveness. We focus on high-quality sourcing, third-party testing, and transparency to bring you a product you can trust.

Will Migraine Defense actually help me? Do you offer any risk-free promise?

We have a 30-day risk-free promise: if you try Migraine Defense as directed for a minimum of 30 days and don't see any improvement, we'll refund your order for up to 60 days after your order date.

Any shipping and handling fees are non-refundable.

Can I take Mindset if I'm pregnant or breastfeeding? 

If you are pregnant or breastfeeding, contact us to get a custom formula tailored for your needs. You should also consult your healthcare provider before starting any new supplement.

Is Migraine Defense formulated by medical professionals?

Migraine Defense is formulated by an expert team that includes board-certified physicians.